Kir3-Based Inward Rectifier Potassium Current
نویسندگان
چکیده
منابع مشابه
Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias.
BACKGROUND We previously characterized a novel K+ current (IKH) with properties of constitutively active acetylcholine-related current in dog atrium. I(KH) is sensitive to tertiapin-Q (IC50 approximately 10 nmol/L), a highly selective Kir3 current blocker. This study assessed the role of IKH in atrial tachycardia (AT)-remodeled canine left atrium (LA) with the use of tertiapin-Q as a probe. M...
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Inward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that the strong inward rectification of cardiac IK1 channels makes it conduct substantial current near the resting potential but carry little or no c...
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RATIONALE Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. Fibroblasts display robust ion currents, but their functional importance is poorly understood. OBJECTIVE To characterize atrial fibroblast inward-rectifier K(+) current (IK1) remodeling in CHF and its effects on fib...
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Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current I(K1) in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studying the effect of 0.2-200 mM ethanol on I(K1) in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp techniqu...
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ژورنال
عنوان ژورنال: Circulation
سال: 2006
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.561738